Vice President Mike Pence and Sen. Kamala Harris are expected to take the debate stage Wednesday night against an extraordinary backdrop that has raised the stakes of an event that for decades has been a routine, inconsequential fixture of presidential elections.

No vice president has debated while the president is known to be sick and possibly still in the hospital. And never have two vice presidential nominees debated at a time when Americans are giving far more than cursory thought to how each might lead in the top job.

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