In an unexpected breakthrough, Sen. Joe Manchin, D-W.Va., reversed his opposition to quickly moving a broad filibuster-proof bill Wednesday and announced he will support a package that includes major investments in drug pricing, as well as provisions to address climate change and taxes on the wealthy.

Manchin announced the agreement in a joint statement with Senate Majority Leader Chuck Schumer, D-N.Y., after months of negotiations between the two appeared to break down recently. The deal represents a major breakthrough for elements of President Joe Biden’s agenda that appeared to be all but dead.

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