Trucks and cargo planes packed with the first of nearly three million doses of coronavirus vaccine fanned out across the country on Sunday as hospitals rushed to set up injection sites and their anxious workers tracked each shipment hour by hour.

The distribution of the first federally approved vaccine marked the start of the most ambitious vaccination campaign in American history, a critical, complicated feat that one top federal official compared to the Allied landings at Normandy during World War II. Now, the United States is trying to turn the tide of battle against a virus whose out-of-control spread has killed nearly 300,000 people, ravaged the economy and upended millions of lives.

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